This project aims to enable subcellular calcium dynamics simulations with physiological realism, for studying the impacts of cardiac pathological changes, including structural changes in the shape and spread of calcium release units, altered number of calcium release channels, and altered gating kinetics of the channels. We also want to enrich the general knowledge about performance optimization of multiple inter-tangled stencil computations, and investigate the possibility of analyzing huge volumes of simulation results in-situ with help of high-speed file cache systems.